Uno occupies a strange spot. It's the highest-selling card game of all time and yet gets dismissed instantly on r/boardgames. The truth is more nuanced: Uno is exactly as good as the context you play it in.
The single biggest discovery for adult players is that stacking +2 and +4 cards is NOT an official rule. Mattel has been emphatic about this — the official rules state that when a +2 or +4 is played, the next player draws and skips their turn, period. Almost every home game allows stacking, which turns the +4 from a guaranteed -4 cards into a high-stakes bluffing game.
The +4 challenge is the most-skipped rule. The Wild Draw 4 is legal only if you have no other matching-colour cards in hand. If challenged and caught lying, YOU draw 4 instead of the opponent. Almost nobody plays this rule, and using it makes Uno into a genuine bluffing game.
For house rules, the community has converged on two improvements: "Jump in" (any player can play an identical card out of turn) and "Seven-Zero" (playing a 7 swaps hands with a chosen opponent; playing a 0 rotates all hands). Both are official Mattel variants and radically change strategy.