Pandemic is the original modern co-op, and almost twenty years on it still defines the genre. The thinning player deck, outbreak chains, and the slow inevitability of an epidemic create a pacing pressure that few thematic games match.
Role choice changes the game meaningfully. The Medic clears outbreaks passively; the Scientist needs only four matching cards for a cure; the Researcher swaps cards freely between players. Mixing roles is the actual strategy.
The Legacy version (Season 1) is still cited as a top-three all-time game by huge swaths of the community. Worth playing through even if you already own the base box.